Biosensors for Phosphorylation

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Biosensors for Phosphorylation

INQUIRY

Protein phosphorylation is a crucial biochemical reaction associated with cancer, metabolic disorders, and many other serious diseases. Currently, most research tools can only detect phosphorylation at a single time point in cell lysates, while tools that can monitor phosphorylation events within living cells in real time are still very limited. Biosensors that can be used to detect a wide range of biological targets have been extensively developed as tools for use in the biological, pharmaceutical, and medical fields. They are expected to be developed as powerful tools for continuous monitoring and accurate measurement of phosphorylation in living cells and can, in turn, accelerate the study of disease mechanisms.

Creative BioMart has developed our biosensor techniques to enable real-time and highly sensitive tracking and visualization of phosphorylation in living cells and organisms. Based on our advanced platform, we can help our customers comprehensively analyze kinases, phosphatases and phosphorylation/dephosphorylation pathways to accelerate their research and drug development process.

Exploring Our Biosensors for Phosphorylation

Genetically-encoded Fluorescent Biosensors

Genetically-encoded FRET biosensors for kinases and second messengers allow real-time monitoring of various metabolites and quantitative imaging of phosphorylation events in living cells.
Electrochemical Biosensors

Gold nanoparticle-based electrochemical biosensors enables simple, rapid, and highly sensitive analysis of kinase activity and monitoring of phosphorylation.
Small Molecule Biosensors

Genetically-encoded small molecule biosensors for kinetic analysis of small molecule interactions with kinases and phosphatases.
Phosphoprotein Biosensors

Phosphoprotein biosensors provide a better understanding of subtle structural changes of phosphoproteins under physiological and pathological conditions.

Applications of Our Biosensors

Enzyme Activity Imaging

Live imaging of kinase/phosphatase activities in living cells and organisms to explore their dynamic behaviors and clarify the regulatory role of phosphorylation/dephosphorylation.
Monitoring Structural Changes

Through monitoring the subtle structural changes in proteins induced by normal and abnormal phosphorylation to uncover underlying mechanisms and its role in diseases.
Drug Discovery

Analysis of biomolecular interactions and drug-target interactions to identify potential targets for the treatment of diseases and develop novel diagnostic tools.

Benefits of Our Biosensors

Real-time

Real-time monitoring of phosphorylation both in vitro and in vivo.
High Sensitivity

High-sensitivity detection of kinase and phosphatase activities in living cells.
High Specificity

Highly specific visualization of protein-protein interactions.
Fast Response

Simple device, easy to use, and short response time.