Phosphoprotein Network AnalysisINQUIRY
Creative BioMart provides overall solutions for the analysis of phosphoprotein network analysis to help elucidate the overall functional consequences of phosphorylation events. Our project team will work closely with our customers to tailor solutions to their needs and keep their research and drug development project moving forward.
Introduction to Phosphoprotein Networks
Protein phosphorylation is a reversible post-translational modification of proteins that may lead to activation or repression of protein activity, as well as alterations in their subcellular localization and interactions with binding partners. Phosphorylation plays an important regulatory role in many biological processes. Therefore, an in-depth study of phosphorylation is essential for understanding the mechanisms underlying these biological processes. However, the numerous forms of protein phosphorylation and the protein-protein interactions (PPI), subcellular localization, and functions specific to each form pose a great challenge for phosphorylation studies. Analysis of phosphoproteins along with their interaction networks is essential to reveal phosphorylation pathways and their functional consequences.
Figure 1. Protein-protein interaction network among altered phosphoproteins. (Shaik A A, et al., 2016)
Computational Phosphoprotein Network Construction and Analysis
Creative BioMart offers computational tools and highly efficient approaches for the construction and analysis of comprehensive phosphoprotein networks across tissues and diseases, helping customers gain preliminary insights into the mechanisms underlying phosphorylation and human diseases to drive drug discovery.
Phosphorylation is one of the key events that control protein-protein interactions. Creative BioMart provides advanced techniques such as circular dichroism (CD), isothermal titration calorimetry (ITC), X-ray crystallography, NMR, and mass spectrometry (MS) to determine protein structure and characterize phosphoprotein-protein interactions.
Various cytokines that play critical roles in cell signaling have been shown to act in relation to intracellular phosphorylation changes. Creative BioMart provides innovative phosphoproteomics solutions and information-theoretic approaches to construct phosphoprotein-cytokine networks for discovering the role of cytokines in health and disease.
Phosphoprotein Networks Across Tissues and Diseases
Phosphoprotein networks are an important framework for studying the relationship between protein phosphorylation, protein function, and cellular processes. Creative BioMart specializes in phosphoprotein network construction and analysis to help elucidate the features of cell-type, tissue, and organ-specific networks, and to understand disease mechanisms.
Custom Protein Production
Protein Analysis Services
Phosphorylation-Specific Antibody Production
Biomolecular Interaction Services
In Vitro Phosphorylation Assays
Identification of Phosphoproteins in Tissues
Creative BioMart is a trusted solution provider with many years of experience in kinase/phosphatase biology research and drug development. We have always been committed to providing our customers with high-quality products and customized services to accelerate their cutting-edge research and drug development pipeline. We fully support your project every step of the way to success.
Contact us to see how we can help you with phosphoprotein analysis and drug development.
- Shaik A A, et al. Phosphoprotein network analysis of white adipose tissues unveils deregulated pathways in response to high-fat diet. Scientific reports, 2016, 6(1): 1-16.
- Ross K E, et al. Construction of protein phosphorylation networks by data mining, text mining and ontology integration: analysis of the spindle checkpoint. Database, 2013, 2013.