Structure Prediction and Analysis of Kinase/Phosphatase Family

Structure Prediction and Analysis of Kinase/Phosphatase Family

INQUIRY

Creative BioMart is committed to accelerating kinase/phosphatase biology research and drug development process by providing professional structural prediction and analysis services. Powered by cutting-edge technologies and highly skilled scientists, we have the ability to handle challenging projects.

Background

Genes are the basic units of inheritance and contain the information necessary for cell survival. Since completion of the Human Genome Project, research hotspots have shifted from genome sequencing to the analysis of genome expression and the prediction of protein structure and function. To fully understand the biological role of proteins, the knowledge of their structure and function is required in addition to the linear amino acid sequences generated by genome sequencing projects. Therefore, predicting the structure of genes and proteins in order to obtain structural models is important and contributes to a deeper understanding of how they work, thus allowing us to control and modify them.

Phosphorylation is a common post-translational modification. Kinases and phosphatases are two sides of phosphorylation. The human genome contains more than 500 protein kinase genes, accounting for about 2% of all human genes. The specificity of substrate recognition of kinases and phosphatases is shaped by the structural and chemical characteristics of both enzymes and substrates. Relative to kinases, phosphatases are more diverse in structure and catalytic mode. Dysfunction of either kinases or phosphatases dose underlie so many human diseases. Structure prediction and modeling of kinases and phosphatases is important to elucidate the physiological functions of these important enzymes. Given the limitations of biological techniques for identifying phosphorylation sites, in silico methods for phosphorylation site prediction are becoming increasingly popular and can aid in the interpretation of human genomic disease variants.

Service Options

Creative BioMart offers a full package of structure prediction and analysis services to meet customer requirements and accelerate their journey to success. If you have any additional questions, please fill out the online inquiry form and let us know more details.

Gene Structure Prediction and Analysis

Elucidating gene structure includes not only nucleic acid secondary structure, but also identification of gene boundaries, splice junctions, and alternative splicing variants. Creative BioMart has a professional team of biologists and bioinformatics to provide our customers with comprehensive gene structure prediction and analysis services covering both DNA and RNA structure prediction based on homology-based prediction, de novo prediction, and transcriptome-based prediction strategies.

Protein Structure Prediction and Analysis

Proteins are heteropolymers of amino acids. Their ability to perform designated biological tasks are directly depend on their structures. Creative BioMart has established an integrated platform covering multiple methods and software for the prediction of the primary, secondary, tertiary, and quaternary structure of proteins. Our services can help customers understand the functions of proteins, the execution of functions, the interactions between biological macromolecules, and the development of medicine and pharmacology, such as drug design.

Complex Structure Prediction and Analysis

Protein complexes are one of the most important functional units involved in multiple biological processes. Creative BioMart has accumulated extensive experience in structure prediction and analysis of protein-protein complex, protein-DNA complex, and protein-RNA complex. We offer our expertise and advanced bioinformatics tools for the structural elucidation of protein complexes involved in numerous fundamental biochemical processes.

Phosphorylation Site Prediction

Identifying and characterizing phosphorylation sites on individual proteins and the proteome is an important step in the analysis of signaling networks. Creative BioMart offers high-throughput, more practical and efficient phosphorylation site prediction services to provides definitive information on functional relationships between signaling proteins.

Creative BioMart has deep knowledge in kinase/phosphatase biology and is specialized in providing structural prediction and modeling services to help customers get new insights into protein phosphorylation. If you are interested in our services, please do not hesitate to contact us.

References

• Bradley D, et al. Sequence and Structure-Based Analysis of Specificity Determinants in Eukaryotic Protein Kinases. Cell reports, 2021, 34(2): 108602.
• Chen M J, et al. Genomics and evolution of protein phosphatases. Science signaling, 2017, 10(474).