Chemical Synthesis of Small Molecules

Chemical Synthesis of Small Molecules

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Chemical Synthesis of Small Molecules


Creative BioMart offers overall solutions for the chemical synthesis of small molecules used as powerful tools for kinase/phosphatase biology research and drug development. We have been offering custom small molecule synthesis services for many years and have accumulated a wealth of experience. We ensure the timely delivery of high-quality products.


Bioactive small molecules offer many advantages because they can be designed to be water-soluble, potent, selective, or cell-permeable. They have been developed as useful research tools for probing numerous biological functions including phosphorylation. Some of them also exhibit activities that disrupt protein–protein interactions or inhibit protein functions. As a result, numerous small molecules have been developed as drugs and have become the mainstay of the pharmaceutical industry. Given that phosphorylation plays an important role in the regulation of virtually all cellular processes and kinases/phosphatases have emerged as one of the most important class of therapeutic targets, small molecules have become essential components of phosphorylation research and the development of targeted drugs. Recently, new classes of small molecules with novel functions such as induction of phosphorylation or controlled dephosphorylation of target proteins have been successfully developed, and they will also find utility in basic research and medicine.

Kinase structure and different types of reversible small-molecule kinase inhibitor.

Figure 1. Kinase structure and different types of reversible small-molecule kinase inhibitor. (Wu P, et al., 2015)

Overall Solutions

  • Design and Synthesis of Small Molecule Inhibitors

    Creative BioMart' experienced scientific team can tackle the design and synthesis of small molecule inhibitors targeting different types of kinases and phosphatases. We can also assist in all stages of drug development, from target identification to preclinical trials, especially in the developing inhibitors to drug the undruggable targets.

  • Design and Synthesis of Small Molecule Probes

    Creative BioMart offers custom design and synthesis of small molecule probes as powerful chemical tools for investigating phosphorylation and studying diseases. Our team of chemical biologists who can bridge the gap between chemistry and biology are capable of assisting in uncovering the mechanism of action of small molecules, making them the starting points for developing drugs.

  • Synthesis of Bifunctional Small Molecules

    Creative BioMart' advanced synthetic platform enables the synthesis of bifunctional small molecules, including proteolysis targeting chimeras (PROTACs), phosphorylation-inducing chimeric small molecules (PHICS), and phosphatase recruiting chimeras (PhoRCs), offering the possibility to manipulate phosphorylation/dephosphorylation and develop novel therapeutic approaches.

  • Synthesis of Other Bioactive Small Molecules

    Creative BioMart offers full capabilities to assist our customers in the chemical synthesis and analysis of their target small molecules for diverse downstream applications in different industries. Our synthetic chemical capabilities cover activators, antagonists, agonists, APIs, intermediates, etc. We provide full support for your R&D and production requirements.

Related Products

Creative BioMart is a trusted solution provider with many years of experience in kinase/phosphatase biology research and drug development. We have always been committed to providing our customers with high-quality products and customized services to accelerate their cutting-edge research and drug development pipeline. We fully support your project every step of the way to success.

Contact Us

Contact us to see how we can help you with phosphatase research and drug development.


  • Wu P, et al. FDA-approved small-molecule kinase inhibitors. Trends in pharmacological sciences, 2015, 36(7): 422-439.
  • Köhn M. Turn and Face the Strange: § A New View on Phosphatases. ACS central science, 2020, 6(4): 467-477.
For research use only. Not intended for any clinical use.