Chemical Genomics and ProteomicsINQUIRY
Creative BioMart offers chemical genomics and proteomics strategies for the systematic analysis of phosphorylation networks, providing extensive resources and support for functional studies and drug development. Our chemical biologists can combine the innovations of chemistry and biology to give new insights into the mechanisms and physiological roles of phosphorylation.
Chemical biology is a rapidly growing scientific discipline that applies chemistry to solve biology problems. Chemical genomics and proteomics use chemical approaches and tools, especially the designed small molecules, to explore the functions of genes and proteins, allowing to solve biological questions that cannot be addressed by genetic manipulation or genomics and proteomics approaches. The ability of chemical genomics and proteomics to identify protein targets of biologically active small molecules with unknown modes of action has illuminated a new paradigm for drug discovery. The surge of scientific interest in phosphorylation signaling networks has led to the application of novel chemical approaches to analyze phosphorylation pathways, leading to exciting advances in our understanding of phosphorylation and in the development of therapeutics targeting kinases/phosphatases. With the cutting-edge technologies in chemical genomics and proteomics, the success rate of finding novel druggable targets is expected to increase and the timeline of drug discovery will be greatly accelerated.
Figure 1. Combined chemical genetics and phosphoproteomics approach to identify cellular downstream targets of protein kinases. (Oppermann F S, et al., 2012)
Chemical Genetics to Chemical Genomics
Small molecule interventions can be used as a complementary strategy to genetic interventions for the study of complex biological systems. Creative BioMart has extensive experience in small molecule synthesis and offers both forward and reverse chemical genetics strategies to obtain a comprehensive understanding of phosphorylation networks through temporal and quantitative control of protein function.
Chemical and Pathway Proteomics
Chemical proteomics for evaluating small molecule-protein interactions has emerged as a powerful technique. Creative BioMart offers advanced enabling tools and methods such as LC-MS, affinity chromatography, and activity-based protein profiling (ABPP) for quantifying and systematically analyzing phosphorylation pathways and revealing therapeutic targets.
Combination of Chemical Genomics and Phosphoproteomics
Combining genomic and proteomic technologies provides important insights into unlocking complex biological functions. Creative BioMart leverages our expertise in chemical genomics and phosphoproteomics to contribute to substrate identification, visualization of kinase/phosphatase activity, in-depth understanding of phosphorylation networks, and discovery of therapeutics and diagnostics.
Data Processing and Statistical Analysis
Creative BioMart has a team of chemical biologists, bioinformaticians, and biostatisticians dedicated to convert raw data into meaningful information. Our team has the ability to analyze and interpret large datasets to explore cellular phosphorylation networks. We will ensure the accuracy and reliability of data collection, processing, and analysis to help our customers get reproducible results.
Creative BioMart is a trusted solution provider with many years of experience in kinase/phosphatase biology research and drug development. We have always been committed to providing our customers with high-quality products and customized services to accelerate their cutting-edge research and drug development pipeline. We fully support your project every step of the way to success.
Contact us to see how our chemical biologists can help you with your project.
- Oppermann F S, et al. Combination of chemical genetics and phosphoproteomics for kinase signaling analysis enables confident identification of cellular downstream targets. Molecular & Cellular Proteomics, 2012, 11(4).
- Zanders E D. Overview of chemical genomics and proteomics. Chemical Genomics and Proteomics, 2012: 3-10.