In Vivo Imaging of Phosphorylation EventsINQUIRY
Creative BioMart offers a full range of advanced techniques and high-quality services for in vivo imaging of kinases, phosphatases, and phosphorylation to advance our customers’ basic research and drug development projects.
In vivo imaging allows for the noninvasive visualization of organisms. Depending on whether biomarkers are required, in vivo imaging can usually be divided into in vivo molecular imaging and anatomical imaging. In vivo molecular imaging can be used for monitoring dynamic real-time localization and translocation of molecules to characterize and measure biological processes at the molecular and cellular levels. Anatomical imaging is often used to observe tissues and organs based on their intrinsic properties. With the development of gene engineering and imaging techniques, in vivo imaging has become real-time, quantifiable, highly sensitive, and compatible with high-throughput applications.
A hallmark of phosphorylation events is their rapid action. Monitoring the rapid phosphorylation-dephosphorylation cycles is essential to elucidate the cellular signaling properties. In vivo imaging can provide the spatial location and dynamic changes of phosphorylation processes, enabling visualization of kinase/phosphatase activity and enzyme-substrate interactions. These advantages make in vivo imaging a very useful technology in kinase/phosphatase biology research and in pharmaceutical fields.
Figure 1. Schematic illustration and bioluminescence from protein kinase A-sensitive luciferase (luciferasePKA). (Moskaug J Ø, et al., 2008)
Creative BioMart has built a technology platform that integrates a wide range of advanced imaging technologies and equipment, allowing us to provide customized in vivo imaging services to our customers.
Creative BioMart has an experienced scientific team with extensive knowledge in kinase/phosphatase biology. We are dedicated to helping our customers achieve high-quality results in a timely and cost-effective manner.
In Vivo Imaging of Kinases and Phosphatases
Kinases and phosphatases play a pivotal role in many physiologic processes and are implicated in multiple diseases, such as cancer. We provide a variety of advanced imaging techniques including transgenic animals and optical imaging for real-time monitoring of kinase and phosphatase activities in living organisms, thus offering the opportunity to elucidate cellular pathways in vivo and discover targeted drugs.
In Vivo Imaging of Phosphorylation
The development of novel in vivo imaging techniques provides new insights into the molecular basis of both physiological and pathological events in living animals. We have established a platform that integrates a diverse array of genetically encoded fluorescent biosensors to observe rapid phosphorylation events in living cells, helping to elucidate complex phosphorylation networks in vivo.
- Real-time and noninvasive in vivo imaging.
- Dynamic and quantitative imaging.
- Various robust animal models and state-of-the-art techniques.
- High-quality and timely feedback.
Creative BioMart is an advanced biotechnology company providing comprehensive services and products to customers engaged in kinase/phosphatase biology research and drug discovery. Our scientific team will work closely with our customers to ensure that the services we provide will actually meet their expectations. If you require further information about any of our services or products, please feel free to contact us at any time. We will get in touch with you as soon as possible.
- Moskaug J Ø, et al. Noninvasive in vivo imaging of protein kinase A activity. Molecular imaging, 2008, 7(1): 7290.2008. 0005.
- Lauber D T, et al. State of the art in vivo imaging techniques for laboratory animals. Laboratory animals, 2017, 51(5): 465-478.