Synthesis of Phospho-Amino Acid AnaloguesINQUIRY
Creative BioMart offers overall solutions for the synthesis of phosphoamino acid analogues to help unravel the mechanisms underlying phosphorylation of great significance for drug development. We have a team of chemical biologists who specialize in applying chemical approaches to solve biological problems and can provide you with useful research tools and innovative ideas.
Introduction to Phosphoamino Acid Analogues
Phosphorylation provides a central regulatory mechanism in biological systems. Protein phosphorylation, which acts as a molecular switch regulating protein activity by causing conformational changes in the phosphorylated proteins, is the basis for numerous cellular processes and many pathological conditions. Most of the protein phosphorylation events occur on serine, threonine, and tyrosine residues. Sometimes, phosphorylation also occurs on other amino acid residues, such as histidine, aspartate, and lysine. Although thousands of phosphorylation sites have been identified, their functions remain to be discovered. Therefore, identifying phosphoamino acids in phosphorylated proteins is an important task. Synthetic phosphoamino acids and their analogues have been developed as essential building blocks for the synthesis of biomarcromolecules such as phosphopeptides. They play a diverse and crucial role as active tools in revealing the structural and functional consequences of protein phosphorylation as well as in advancing biomedical research. However, the routine synthesis of phosphoamino acid analogues remains challenging.
Figure 1. Phosphoamino acids and their mimics. (van Kasteren S., 2012)
Synthesis of Phosphoserine, Phosphothreonine and Phosphotyrosine Analogues
Creative BioMart' protocols have been proven to enable the efficient synthesis of phosphoserine, phosphothreonine, and phosphotyrosine and their analogues. Our scientists are dedicated to helping our customers unravel the mechanism and physiological functions of serine/threonine/tyrosine phosphorylation in both eukaryotes and prokaryotes.
Synthesis of Analogues of Other Phosphorylated Amino Acids
Creative BioMart has also developed strategies for the synthesis of other phosphoamino acids that are also biologically important, including phosphohistidine, phosphoarginine, phospholysine, phosphoaspartate, and phosphoglutamate. Our synthesis strategy is optimized for each type of amino acid.
Synthesis of Nonhydrolysable Analogues of Phosphoamino Acids
Creative BioMart has the ability to synthesize nonhydrolyzed analogues of phosphoamino acids according to customers' needs, helping them prepare phosphopeptides for the development of antibodies and inhibitors.
Synthesis of Photoregulated Phosphoamino Acid Analogues
Creative BioMart provides an innovative strategy for synthesizing photoregulated phosphoamino acid analogues to provide our customers with powerful tools that enable spatiotemporal control of biological processes regulated by phosphorylation.
Custom Peptide Synthesis
Custom Protein Production
Phosphorylation-Specific Antibody Production
Creative BioMart is a trusted solution provider with many years of experience in kinase/phosphatase biology research and drug development. We have always been committed to providing our customers with high-quality products and customized services to accelerate their cutting-edge research and drug development pipeline. We fully support your project every step of the way to success.
Contact us to see how our chemical biologists can help you with your project.
- van Kasteren S. Synthesis of post-translationally modified proteins. Biochemical Society Transactions, 2012, 40(5): 929-944.
- Spicer C D, et al. Synthesis of phospho-amino acid analogues as tissue adhesive cement additives. ACS central science, 2020, 6(2): 226-231.