Protein phosphorylation, one of the most common post-translational modifications, plays a key regulatory role in diverse cellular functions including cell cycle, cell growth and apoptosis, signal transduction, metabolism, and oncogenesis. All phosphorylated proteins in the proteome are referred to as the phosphoproteome. As a branch of proteomics, phosphoproteomics aims to provide a comprehensive analysis of the phosphoproteome, including the identification and quantification of phosphorylation status, to facilitate a better understanding of phosphorylation events in health and disease.
Creative BioMart has established a high-throughput and highly sensitive mass spectrometry-based phosphoproteomics platform for global phosphoproteome analysis. Our project team can execute the whole workflow from protocol design, protein extraction and digestion to phosphopeptide enrichment and separation and downstream data analysis, providing our customers with reliable and high-quality results that meet their requirements.
Exploring Our Phosphoproteomics Platform
Global and site-specific quantitative phosphoproteomics encompass modular quantitative methods to dig deeper into the comprehensive phosphorylation events and delineate signaling pathways.
Mapping differential phosphorylation events in signaling networks to determine specific functions of each phosphorylation in different biological events and to create a functional landscape of the phosphoproteome.
Large-scale comparative phosphoproteomics, which allows comparative analysis of phosphoproteomes, can reveal the evolutionary and functional conservation of phosphorylation across different species.
Chromatin phosphoproteomics enables the identification of chromatin-associated phosphorylation events and phosphorylated chromatin targets by linking cytoplasmic signaling to chromatin events.
Applications of Our Phosphoproteomics Platform
Cell Signaling Research
Phosphoproteomic-based studies provide the opportunity to understand signaling pathways at the systems level and advance our understanding of complex cellular signaling events.
Plant Biology Research
Plant phosphoproteomics enables the identification of the rapid plant responses to external stimuli by detecting rapid changes of phosphorylation in plants, thus promoting the development of plant biology.
High-throughput identification and quantitation of phosphorylation on a global scale to analyze the phosphoproteome changes during disease progression to reveal pathogenic mechanisms and key pathogenic proteins.
Drug Discovery & Development
A complete understanding of the role of phosphorylation in diseases and the effects of drugs on phosphorylation can deliver high informative data for drug discovery and development.
Disease Biomarker Discovery
Analysis of phosphorylation in different physiopathological states can further uncover important biomarkers associated with disease development and facilitate precision medicine.
Benefits of Our Phosphoproteomics Platform
Highly Efficient Enrichment
Advanced enrichment strategies and flexible protocols to overcome challenges in phosphoproteomics associated with the low abundance of phosphoproteins and phosphopeptides.
A scalable high-throughput phosphoproteomics platform that allows rapid quantification and deep profiling of phosphoproteomes in different cells and tissues.
Equipped with state-of-the-art high sensitivity mass spectrometry to improve the sensitivity and performance of phosphoproteomics studies.
Professional Data Analysis
An experienced scientific team helps you analyze large amounts of proteomics data to uncover key information and overcome analytical challenges in global studies of phosphorylation.
Take the Next Step
See how our advanced technology platform can help you maintain your leading position in phosphorylation research and drug development.