Phosphatase Interactome Platform

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Phosphatase Interactome Platform

INQUIRY

When it comes to phosphorylation research, most of the scientific interest has focused on kinases rather than phosphatases. However, a growing number of studies have shown that phosphatases also play an important role in many physiological processes by coordinating with kinases to regulate phosphorylation levels. Disturbed phosphorylation balance can also lead to diseases such as cancer. Since the current understanding of phosphatase functions and their interactions is still fragmented, there is an urgent need to comprehensively analyze the phosphatase interactome to give a global view of the interactions between phosphatases and their substrates and define the function of poorly characterized phosphatases.

Creative BioMart integrates affinity proteomics, label-free quantitative proteomics, advanced mass spectrometry technologies, and bioinformatics analysis to provide our customers with a global view of phosphatase interaction networks. Our team of scientists with extensive experience in phosphatase interaction analysis and cell signaling research is dedicated to helping our customers identify critical nodes in phosphatase interaction networks to advance their research to the next stage.

Exploring Our Phosphatase Interactome Platform

Affinity Proteomics

Combining affinity proteomics and network context to identify protein interactors that may be potential substrates and create interaction networks to characterize the phosphatase interactome.
Label-free Quantitative Proteomics

Combining label-free quantitative proteomics and statistical tools to avoid interference of background contaminants on true interactions and identify high-confidence interactions.
Mass Spectrometry

Advanced mass spectrometry technologies including LC-MS, LC-MS/MS, AP-MS, XL-MS allow global mapping of the phosphatase interactome.
Bioinformatics Analysis

A team of bioinformatics, biostatisticians and software engineers supports the global analysis of phosphatase interactions and characterization of interaction networks through the use of specialized tools, software, and databases.

Applications of Our Phosphatase Interactome Platform

Biological Research

Uncovering phosphatase interactions involved in numerous cellular functions and pathological processes to further understand the functional role of these interactions.
Disease Research

Linking phosphatase interactomes to disease phenotypes and elucidating these interaction networks can help decipher the pathogenesis of these diseases.
Biomarker Discovery

Analyzing disease-related phosphatase interactomes to identify key regulators as potential biomarkers for diagnosis and prognosis of diseases.
Drug Discovery

A global analysis of the phosphatase interactome offers promising targets and additional choices for the treatment of a variety of diseases.

Benefits of Our Phosphatase Interactome Platform

Highly Integration

Integrating a wide range of assays/techniques, bioinformatics strategies, and interactome databases for comprehensive profiling in vitro and in vivo phosphatase interactomes.
High-Throughput

A high-throughput platform for measuring spatiotemporal changes in the phosphatase interactome with the advantages of high sensitivity, high speed, and low cost.
Broad Applications

Interactome analysis can be performed on almost all kinds of phosphatases from different species to achieve different purposes in biological and biomedical research.
Professional Data Analysis

An experienced scientific team is dedicated to uncovering key information from the vast amount of bioinformatics and experimental results.