Antibody Engineering for Phosphorylation Research

Antibody Engineering for Phosphorylation Research

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Antibody Engineering for Phosphorylation Research


Creative BioMart provides a full range of antibody engineering services to support kinase/phosphatase biology research and pharmaceutical development projects. As a leading biotechnology company, we are confident to complete challenging projects in a short amount of time.

Introduction to Antibody Engineering

The significance of antibodies as indispensable analytical tools in basic research and as diagnostic reagents has been well known and exploited. In recent years, antibodies have become increasingly accepted as effective targeted therapeutic agents. With the development of modern molecular biology techniques, it has become possible to engineer antibodies of interest to suit diverse applications. Antibody engineering involves the modification of antibody sequences and/or structures to improve their biochemical and biophysical properties, making them ideal research tools and therapeutics. Antibody engineering aims at producing highly specific, effective, and stable antibodies. Advanced antibody engineering techniques have great application prospects in the field of kinase/phosphatase biology, diagnostics, and therapeutic medicines.

Anaplastic lymphoma kinase (ALK) domains and binding of single-chain variable fragment (scFv)-107.

Figure 1. Anaplastic lymphoma kinase (ALK) domains and binding of single-chain variable fragment (scFv)-107. (Stylianou D C, et al., 2009)


Creative BioMart has a highly experienced team of professionals to handle the production of different types of engineered antibodies. We also provide a full set of services from antigen preparation to antibody analysis to help our customers obtain the required antibodies as soon as possible.

Types of Engineered Antibodies
Monoclonal antibody Polyclonal antibody Recombinant antibody
Phosphorylation-specific antibody Anti-idiotypic antibody Single domain antibody
Bispecific antibody Bivalent antibody IgG antibody
Diabody Triabodies Tetrabodies
Minibody F(ab) and F(ab')2 fragments dsFv, and scFv fragments

Service Options

Creative BioMart has successfully complete numerous challenging antibody engineering projects, helping our customers save time and effort. We offer a wide selection of antibody engineering strategies and advanced technologies to meet the specific needs of each project. Our service options include, but are not limited to the following:

Service Options Details
Antibody fragmentation
  • Digestion or cleavage of immunoglobulins into their constituent components.
  • A complete set of services from dialysis, digestion, concentration, to purification of antibody fragments.
Antibody conjugation
  • Antibodies conjugated with enzymes, biotin, fluorochromes, oligonucleotides, nanoparticles, drugs, or other moiety (e.g. PEG).
  • Various types of labels/conjugates for diverse applications.
Antibody sequencing
  • Essential for antibody engineering and further functional optimization.
  • Fully customizable sequencing services with guaranteed sequence accuracy and fast turnaround time.
Epitope mapping
  • Identifying the binding site of an antibody on its target antigen and elucidating the binding mechanisms.
  • High-resolution conformational epitope mapping for complex proteins and conformational epitopes.
Antibody reformatting
  • Reformatting the variable region of a given immunoglobulin into a variety of different fragments.
  • Re-engineering antibodies and antibody fragments into Fab, F(ab)'2, scFv, VHH, minibodies, and other formats.
Antibody affinity maturation
  • Improving antigen-binding affinity of antibodies.
  • Tailored antibody affinity maturation protocol for antibodies from different species.
Antibody humanization
  • Reducing the immunogenicity of monoclonal antibodies from non-human species.
  • Different humanization strategies and a well-established platform for the evaluation of antibodies.

* If you can't find what you are looking for in the options above, please fill out the online inquiry form and let us know more details.

Creative BioMart provides comprehensive and flexible custom antibody engineering services to match the specific needs of our customers. We also have a comprehensive range of antibody products. If you are interested in our services or products, please do not hesitate to contact us.


  • Stylianou D C, et al. Effect of single-chain antibody targeting of the ligand-binding domain in the anaplastic lymphoma kinase receptor. Oncogene, 2009, 28(37): 3296-3306.
  • Jain M, et al. Engineering antibodies for clinical applications. Trends in biotechnology, 2007, 25(7): 307-316.
For research use only. Not intended for any clinical use.