Overall Solutions for KinasesINQUIRY
Creative BioMart has a wide range of products and services with coverage of almost all types of kinases, enabling us to provide overall solutions for kinase research and drug development. Our experienced and skilled scientists have the ability to customize solutions for specific kinase targets. We will work closely with our customers to meet their research needs.
Introduction to Kinases
Kinase is a word derived from the Greek word kinein which means “to move”. Kinases are enzymes that modify the function of other molecules, such as proteins, lipids, and nucleic acids, by adding catalyzing the transfer of phosphate from ATP onto them. This process is known as phosphorylation. Kinases regulate a variety of functions critical to the survival of the organism through phosphorylation of substrates. They are ubiquitous enzymes, present in every cell of every species, and are key controllers of most signaling pathways and cellular functions. A large number of kinase-encoding genes have been identified in the human genome and have been shown to be important in health and disease. A growing number of kinases have been shown to be associated with human diseases, and they have become prominent therapeutic targets.
Figure 1. The basic catalytic cycle for substrate phosphorylation by a kinase. (Ubersax J A & Ferrell Jr J E., 2007)
Creative BioMart offers a complete portfolio of high-quality kinase-related products, including kinase antibodies, gene editing tools, kinase cells & biological fluids, and small molecules targeting kinases to fully support kinase research and exploration of phosphorylation events.
Creative BioMart is specialized in kinase screening & profiling, kinase substrate identification, and phosphorylation analysis. Our scientists offer their expertise to develop and validate in vitro and in vivo assays to meet a wide variety of customer needs.
Creative BioMart provides innovative researchers with a core technology platform covering a variety of advanced technologies such as mass spectrometry, chromatography, bioinformatics, and high-throughput screening to help them turn their ideas into reality.
Extending Kinome Coverage
Creative BioMart provides overall solutions with complete coverage of the human kinome, eukaryotic kinome, and microbial kinome. We are committed to extending the druggable kinome to advance new kinase drug discovery projects.
Creative BioMart is a leading biotechnology company with many years of experience in kinase/phosphatase biology research and drug development. We are a trusted kinase solution provider that can accelerate the cutting-edge projects of our customers with a portfolio of high-quality products and customized services. We provide full support to help accelerate the drug development pipeline.
Contact us to see how we can help you with kinase research and drug development.
- Ubersax J A & Ferrell Jr J E. Mechanisms of specificity in protein phosphorylation. Nature reviews Molecular cell biology, 2007, 8(7): 530-541.
- Shapiro P, et al. Introduction to Kinases, Cellular Signaling, and Kinase Inhibitors. Next Generation Kinase Inhibitors. Springer, Cham, 2020: 1-12.