Custom Peptide Conjugation and Modification for Phosphorylation Research
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INQUIRYCreative BioMart offers numerous options for custom peptide conjugation and modification to accelerate kinase/phosphatase biology research and pharmaceutical development. Our extensive experience in custom peptide synthesis services allows us to deliver high-quality peptide conjugates or modified peptides within a guaranteed time.
Background
Peptides have the ability to bind to larger interfacial pockets and can be chemically modified to improve stability, affinity, and specificity. They have attracted a lot of attention in recent decades. The number of approved peptides biotherapeutics is also increasing. Peptide conjugates and modified peptides have been the subject of intensive research over the years due to their high potential. They hold a prominent position in the field of life sciences and biomedicine. Peptide conjugates can be used as substrates for kinases and phosphatases. Mono- and multi-phosphorylated peptides are crucial to study phosphorylation events. They play important roles in kinase/phosphatase biology and the development of drugs targeting kinases and phosphatases.
Figure 1. Chemical approaches for the synthesis of phosphopeptides. (Samarasimhareddy M, et al., 2020)
Available Services
Creative BioMart offers comprehensive peptide conjugation and modification services to meet any research need. Our scientific team is dedicated to helping our customers choose and optimize the most appropriate peptide conjugation and modification approach for each project. Our services include, but are not limited to the following:
| Peptide Conjugation | |
| Peptide-BSA conjugation | Peptide-KLH conjugation |
| Peptide-OVA conjugation | Peptide-enzyme conjugation |
| Peptide-DNA conjugation | Peptide-RNA conjugation |
| Peptide-oligonucleotide conjugation | Peptide-antibody conjugation |
| Peptide-drug conjugation | Peptide-carrier conjugation |
| Peptide-fatty acids conjugation | Peptide-nanoparticle conjugation |
| N-Terminal Modifications | |
| 3-Mercaptopropyl (Mpa) | FITC |
| 5-FAM | Fmoc |
| 5-FAM-Ahx | Formylation |
| Abz | Hexanoic acid |
| Acetylation | HPP(4-Hydroxyphenylpropionic acid) |
| Acryl | HYNIC |
| Alloc | Lauric acid |
| Benzoyl | Lipoic acid |
| Benzyloxycarbonylation (CBZ) | Maleimide |
| Biotin | MCA (7-Methoxycoumarinyl-4-acetyl) |
| Biotin-Ahx | Myristoyl |
| Boc (Tertbutoxycarbonyl) | Octanoic acid |
| Br-Ac- | Palmytoyl |
| Chenodeoxycholic acid | Pentinoic Acid |
| D (+) Glucose | Propiolic Acid |
| Dansyl | Pyroglutamyl (pGlu) (Pyr) |
| Dansyl-Ahx | Stearic acid |
| Decanoic acid | Succinylation |
| DNP (2, 4-Dinitrophenyl) | Thioester |
| DTPA | TMR |
| C-Terminal Modifications | |
| Acryl | KLH (-COOH of C terminal) |
| AFC | MAPS Asymmetric 2 branches |
| AMC (7-Amino-4-Methylcoumarin) | MAPS Asymmetric 4 branches |
| Amidation | MAPS Asymmetric 8 branches |
| Bzl | Me |
| CMK (Chloro-methylketones) | NHEt |
| C-terminaleaters | NHisopen |
| Cysteamide (Mercaptoacetamide) | NHMe |
| Ester (OEt) | OBzl |
| Ester (OMe) | OSU |
| Ester (OtBu) | p-Nitroanilide (pNA) |
| Post-Translational Modifications | |
| Acetylation | Methylation |
| ADP-ribosylation | Myristoylation |
| Carbamylation | Palmitoylation |
| Carboxylation | Phosphorylation |
| Citrullination | Polyglycylation |
| Deamidation | Prenylation |
| Formylation | Pyrogutamate |
| Glycosylation | Sulfation |
| Hydroxylation | SUMOylation |
| Lipidation | Ubiquitination |
| Others | |
| Unusual & non-natural amino acids | Cyclic modifications |
| Peptide labeling | Peptide dimers |
If you can't find what you are looking for in the options above, please fill out the online inquiry form and let us know more details.
Custom Project Workflow
Our Advantages
- State-of-the-art techniques and a wealth of successful experience.
- Guaranteed quality, quantity, purity, and consistency.
- Peptide conjugated or modified peptides are delivered along with a Certificate of Analysis.
- Scalable platform and customized services for specific needs.
- Fast turnaround time and competitive price.
Creative BioMart provides comprehensive and flexible peptide conjugation and modification services. Our innovative techniques coupled with our large collection of products allow us to tackle your project to save your time and effort. If you require any further information, please feel free to contact us. We look forward to working together to meet your goals.
References
- Samarasimhareddy M, et al. Multiphosphorylated peptides: importance, synthetic strategies, and applications for studying biological mechanisms. Organic & biomolecular chemistry, 2020, 18(18): 3405-3422.
- Boutureira O & Bernardes G J L. Advances in chemical protein modification. Chemical reviews, 2015, 115(5): 2174-2195.